APOE and atherosclerosis: To explore the potential effects of miR166a-3p derived from CDNVs in ApoE-/- mice fed a high-fat diet, we developed in vivo miR166a-3p mimics (agomiR166a-3p) and inhibitors (antagomiR166a-3p), and assessed their effects on body weight, lipid metabolism, inflammation, and atherosclerosis (AS).