Notably, a deafness-related missense mutation rs72474224 (p.Val37 Ile) located in the GJB2 gene showed a higher allele frequency in the southern East Asian population including HM [39] (Yao-T:0.153; Miao-T:0.250; She-T:0.278) but a lower frequency in other populations in the world (Fig. 6a) [40]. The gene discussed is GJB2; the disease is deafness.