RRP15, a potential HCC biomarker and therapeutic target, upregulates LAMC2 through the transcription factor PATZ1, which promotes the migration of HCC cells (Fig. 5H), whereas knockdown of RRP15 inhibits the migration of HCC by attenuating LAMC2/integrin β4/FAK signaling. The gene discussed is LAMC2; the disease is hepatocellular carcinoma.