ITGB4 and hepatocellular carcinoma: To further determine whether RRP15 knockdown suppressed HCC migration in a LAMC2-dependent manner, we simultaneously overexpressed RRP15 and knocked down LAMC2 in both cell lines (Fig. 4A, B), and found that overexpression of RRP15 increased ITGB4 protein levels, and those of phosphorylated FAK, ERK and p65 NF-κB.