Besides, to further assess the association between circulating levels of asprosin and obesity in children, specifically, the association between asprosin and body mass index (BMI); BMI standard deviation score (BMI-SDS); HOMA-IR; age; total cholesterol (TC); triglycerides (TG); high-density lipoprotein cholesterol (HDL-C); low-density lipoprotein cholesterol (LDL-C); insulin; fasting blood glucose (FBG) and TNF-α, respectively, the Spearman or Pearson correlation coefficients of each study were recorded. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.