Moreover, the original data on homeostasis model assessment of insulin resistance (HOMA-IR), circulating levels of tumor necrosis factor-alpha (TNF-α) and adiponectin, which reflecting the biochemical features of obesity, were analyzed as mean difference (MD) and the 95% CI, since they got an approaching magnitude and consistent unit respectively. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.