H. pylori infection leads to chronic inflammation, the formation of advanced glycation end products, and the production of vasoactive substances such as interleukin and leukotriene, reducing the levels of C-peptide, affecting insulin secretion, increasing insulin resistance, accelerating the decline of islet β-cell function, and finally leading to glucose metabolism disorders, leading to elevated blood sugar that is difficult to control [33]. This evidence concerns the gene INS and glucose metabolism disease.