For 90-day HF rehospitalization (Supplementary Table S13-14), GDF-15 levels at discharge demonstrated a significant association with increased hazard and incidence of 90-day HF readmission in both univariate (CSHR 1.71, CI 1.04–2.84; SDHR 1.69, CI 1.14–2.52) and multivariate analyses (CSHR 2.10, CI 1.15–3.82; SDHR 2.06, CI 1.20–3.56). This evidence concerns the gene GDF15 and hydrops fetalis.