The study found that the combination of GDF-15 and NT-proBNP (AUC = 0.905, 95%CI: 0.868–0.942, P < 0.001) outperformed NT-proBNP alone (AUC = 0.869, 95%CI: 0.825–0.913, P < 0.001) in HF. This evidence concerns the gene GDF15 and hydrops fetalis.