In addition to PSA, FAM3B was the only other differentially regulated protein in our data (log2FC = -1.4, FDR p.value = 0.02 in Serum.DDA.TMT) that was both actively secreted and with RNA specific expression in prostate cancer (40.3 FPKM according to HPA). Here, FAM3B is linked to Familial prostate cancer.