BCL2 and breast cancer: Natural and synthetic chalcones have emerged as important molecules with various therapeutic properties as anticancer effects [5], including cytotoxicity for a wide range of cancer types, such as leukemia, hepatoma, colorectal cancer, stomach cancer, prostate cancer, epidermoid carcinoma, and breast cancer, through a mechanism than involve apoptosis induction by death receptor activation or Bcl-2 family protein regulation.