Apart from ANAs, other autoantibodies, such as anti-Smith (anti-Sm), anti-ribonucleoprotein (anti-RNP), the B-cell activation factor (BAFF), a proliferation-induced ligand (APRIL), anti-TRIM21/TROVE2 circulating autoantibodies, and anti-histone antibodies, are also commonly observed in SLE and contribute to the clinical heterogeneity of the disease [108,109]. This evidence concerns the gene TRIM21 and systemic lupus erythematosus.