GDF15 and obesity due to melanocortin 4 receptor deficiency: More insights into the genetic variants of GFRAL—together with a more comprehensive knowledge about the control of the transcription and translation of GFRAL under disease conditions, as well as further explanations of GDF15-mediated effects beyond the AP/NTS—could be relevant for the development of novel pharmacological therapies for physical and mental disorders related to body image and food intake, such as eating disorders, cachexia and obesity.