TBC1D4 and type 2 diabetes mellitus: In a recent study, Manousaki et al. have reported that the TBC1D4 mutation was present in 27% of Canadian and Alaskan Inuit (heterozygote or homozygote carriers) [55], which suggests that pre-diabetes and T2D might be underdiagnosed among Canadian Inuit, unless post-prandial values are tested.