Of relevance in this context, resveratrol has been shown in preclinical studies to modulate Th17 differentiation via the activation of Sirt-1, leading to the suppression of the p300-activated STAT3 signaling cascade, thereby stimulating Treg and Th2 differentiation [222], suggesting that this natural multifunctional agent may offer a promising approach to restore enhanced immune function in BC patients. The gene discussed is STAT3; the disease is breast cancer.