To our knowledge, this is the first research to focus on enhanced NF-κB activity in Gem-resistant PaCa and to show associations of parthenolide with the suppressed invasive potential, the production of angiogenic factors such as VEGF and IL-8, and an improved Gem sensitivity via the suppression of MRP1 expression. Here, CXCL8 is linked to permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.