After measuring the levels of pro-inflammatory cytokines in the serum of each group of mice, we found that compared to the control group, the levels of TNF-α (p < 0.001), IL-1β (p < 0.01), and IL-6 (p < 0.05) were significantly increased in the serum of mice with DSS-induced colitis. The gene discussed is TNF; the disease is colitis.