GLI2 and breast cancer: Of interest, among RSV-hypermethylated targets in MCF10CA1a breast cancer cells, a gene with the highest magnitude of change, GLI2 (Figure 1B), is a transcriptional co-activator of Hedgehog signaling, which crosstalks with the Wnt pathway, for example, through the inhibitory action of GSK3-beta on both GLI and beta-catenin [29].