WNT4 and breast carcinoma: Because DNA hypermethylation was the highest at WNT4 among identified hypermethylated WNTs, and WNT4 is a Wnt ligand shown to be particularly upregulated in breast cancer [59] and in subsets of breast cancer expressing autocrine human growth hormone (hGH) that drives transformation [60], we proceeded with the investigation of GLI2 and WNT4.