Reactive Oxygen Species (ROS) mediated oxidative damage is a common denominator in As pathogenesis [68].As-triggered T2DM has been reported to contribute to the mitochondrial overproduction of ROS [12], and compensatory As-induced oxidative stress leads to an increase in the activity of antioxidant enzymes, such as total glutathione [27,29], superoxide dismutase, catalase, and glutathione-S-transferase activity [27]. The gene discussed is HPGDS; the disease is type 2 diabetes mellitus.