According to Oriquat, Spirulina could alleviate non-alcoholic fatty liver disease (NAFLD) through the modulation of the hepatic expression of miR-122, miR-34a, and miR-21, as well as the SREBP-1c, SIRT1, and HPB1 genes [100]. This evidence concerns the gene SIRT1 and metabolic dysfunction-associated steatotic liver disease.