SFN altered integrin β1 and β4 such that the bladder cancer cell lines investigated here switched from collagen to fibronectin binding (e.g., partially RT112), lost contact to collagen and/or fibronectin (e.g., partially T24, TCCSUP), and/or firmly attached to matrix proteins (e.g., partially RT4). Here, FN1 is linked to urinary bladder cancer.