A study conducted in North America and Canada [78] investigated how the adoption of certain lifestyle behaviors, such as alcohol, coffee, and tobacco consumption, can influence the clinical course of chronic hepatitis B. Clinical markers of the severity of liver damage, such as alanine aminotransferase (ALT) levels and Fibrosis-4 score (FIB-4), were analyzed in a group of 1330 subjects. The gene discussed is GPT; the disease is chronic hepatitis B virus infection.