Although widely used in clinical settings, classical biomarkers like calcium (Ca), phosphorus (P), parathyroid hormone (PTH), bone-specific alkaline phosphatase (BALP), osteocalcin, type I procollagen extension peptides (P1NP and P1CP), amino-NTX1- and carboxyl-terminal cross-linked telopeptides (CTX1- for type 1 collagen) have limitations, including low specificity (due to synthesis in tissues other than bone), low sensitivity, susceptibility to dietary, age, gender, or circadian rhythm influences, and potential alteration in the presence of renal failure. Here, PTH is linked to Renal insufficiency.