IGHE and food allergy: The development of other allergic conditions, late tolerance, or multiple food allergies in non-IgE-mediated cases can be attributed to many different mechanisms involving innate immunity, innate lymphoid and T-regulatory cells, proinflammatory cytokines, eosinophils, abnormal permeability, skin barrier disruption, exposure to allergens, gut microbiota and related metabolites [26,27].