IL18 and obesity due to melanocortin 4 receptor deficiency: One study found a significant interaction between cholesteryl ester transfer protein (CETP) polymorphism and DIL and DII and their effect on obesity indices (waist circumference and BMI), lipid profiles (triglycerides, high-density lipoproteins (HDL) and low-density lipoproteins (LDL) to high density lipoprotein ratio, inflammatory markers (interleukin-18, C-reactive protein, and prostaglandin F2-α), and antioxidant markers (total antioxidant capacity and superoxide dis-mutases)) in patients with T2DM.