As a result, the ethyl ester prodrug NRD167 (Figure 5D) was developed, which selectively decreased the proliferation of Sirt5-dependent acute myeloid leukemia (AML) cell lines with IC50 values of 5–8 μM, induced apoptosis at similar concentrations, and disrupted cellular oxidative phosphorylation and glycolysis, recapitulating the effects observed upon Sirt5 knockdown in Sirt5-dependent AML cells [202]. This evidence concerns the gene SIRT5 and acute myeloid leukemia.