SIRT3 and triple-negative breast carcinoma: ADTL-SA1215 exhibited Sirt3-dependent cellular activity, increasing Sirt3 deacetylase activity ~two-fold and decreasing acetylation of the Sirt3 substrate manganese superoxide dismutase (MnSOD) at lysine-68 and -122 in the MDA-MB-231 triple-negative breast cancer cell line in a concentration-dependent manner [62].