Notably, MDL-800 decreased acetylation of the Sirt6 substrates histone H3K9 and H3K56 in human hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC) cell lines in a concentration-dependent manner and induced Sirt6-mediated G0–G1 phase cell cycle arrest [105,106]. This evidence concerns the gene SIRT6 and hepatocellular carcinoma.