Thiazoles as a scaffold for Sirt2 inhibition have continued to be investigated; the thiazole MIND4 (Table 2) was found to inhibit Sirt2 with an IC50 value of 3.5 μM and independently activate nuclear factor erythroid 2-related factor 2 (NRF2), resulting in synergistic neuroprotection in several models of Huntington’s disease [131]. The gene discussed is NFE2L2; the disease is juvenile Huntington disease.