Moreover, the derivative II illustrated powerful cytotoxicity against colorectal HCT-116, SW480, ovarian SKOV3, glioblastoma U87 and breast SKBR3 cancer cell lines, with IC50 values ranging from 3.83 to 11.94 μM when compared to erlotinib through EGFR inhibition behavior [33]. This evidence concerns the gene EGFR and cancer.