TRPV4 and digestive system disorder: TRPV4 modulators can be used as therapeutic targets for a variety of diseases, such as TRPV4 activators that reduce atherosclerotic plaque formation [7,8], promote the proliferation of adult hippocampal dentate gyrus neural stem cells [9,10], and promote angiogenesis and arteriogenesis [11,12], and TRPV4 antagonists that treat edema, pain, gastrointestinal disorders, and pulmonary disorders [13,14].