PADI3 and clear cell renal carcinoma: It has been reported that PADI3 is highly expressed in some solid tumors, such as bladder, pancreatic, cervical, head and neck, and clear-cell renal cancers, in which increased PADI3 enhances the citrullination of the glycolytic rate-limiting enzyme PKM2, leading to increased levels of glycolysis [17,18].