Moreover, it interferes with estrogen/androgen signals to inhibit prostate hyperplasia in Wistar rats [58] and improves the disorder of prostate epithelial cells and abnormal proliferation of connective tissue in Wistar rats with BPH model, inhibiting Proliferating Cell Nuclear Antigen (PCNA), Androgen Receptor (AR), and estrogen receptor α (Erα) Protein expression while promoting estrogen receptor β (ERβ) Protein expression while promoting ERβ Protein expression [122]. Here, ESR1 is linked to benign prostatic hyperplasia.