The association of lysosomes to kinesins is mediated by Arl8b and the BORC complex, and a high expression of both Arl8b and the BORC-subunit proteins, BLOC1S2 and BORCS5, are correlated to a poor prognosis and an increased invasive capacity in breast cancer and prostate cancer, respectively [295,299]. Here, ARL8B is linked to prostate carcinoma.