In the intricate network of glioma pathogenesis, the YTHDF family, consisting of YTHDF1, YTHDF2, and YTHDF3, and YTHDC1 and YTHDC2, as members of the YTH domain-containing family, play significant roles in the prognosis and molecular mechanisms underlying glioma [158]. The gene discussed is YTHDF1; the disease is central nervous system cancer.