Westeneng et al. developed the ENCALS score, a personalized prediction model based on clinical parameters, such as age of onset, diagnostic delay, progression rate, forced vital capacity, bulbar onset, definite ALS according to the El Escorial criteria, the presence of frontotemporal dementia, or a C9orf72 repeat expansion. Here, C9orf72 is linked to amyotrophic lateral sclerosis.