Accumulating evidence in cardiac studies suggests that, under basal conditions, the involvement of PINK1-Parkin in mitophagy is limited, but it becomes significantly pronounced during stress conditions such as myocardial infarction or disruption of mitochondrial fission due to Drp1 deletion in cardiomyocytes [73,74,75,76]. This evidence concerns the gene PRKN and myocardial infarction.