Assays using TH006 confirmed that this PROTAC could penetrate inside the cells and induce intracellular tau degradation in a dose- and time-dependent manner in tau-overexpressing Neuro-2a cells, tau-overexpressed human neuroblastoma-derived SH-SY5Y cells, and primary neuron cells derived from the 3xTg-AD transgenic mouse model. Here, MAPT is linked to Alzheimer disease.