IL-10 is known to be a potent immunoregulatory cytokine, suppressing macrophage activity and DC maturation and inhibiting IL-12 production by DCs, thereby impairing the Th1 immune response and IFN-γ production [81], which limits immune response against intracellular parasitic infection, being associated with the persistence of the parasite at the site of infection [82]. The gene discussed is IFNG; the disease is parasitic infectious disease.