RUNX3 and urinary bladder carcinoma: Simultaneously, ROS directly induced LINE-1 hypomethylation and RUNX3 promoter hypermethylation in bladder cancer cell lines, uroepithelial cell carcinogenesis [21], and hepatocellular carcinoma (HCC), making ROS-induced RUNX3 hypermethylation promising as a practical and valuable biomarker for diagnosis [22,23] (Figure 1).