Intensive ROS scavenging, including peroxiredoxin 1 (PRDX1) [27], SOD2 [28], CAT, GSH-PXs, thioredoxins (TRXs), and GSH, can be upregulated by the activation of TNFα, Nrf2, HIF1α, AMPK, and PGC1α, protecting cancer cells from damage and subsequent cell death [29,30]. The gene discussed is PRKAA1; the disease is cancer.