SNAI1 and neoplasm: For example, high levels of ROS in tumor cells activate NF-κB, promoting transcription factor (Snail) expression, downregulating epithelial calmodulin (E-cadherin), and promoting the expression of neural calmodulin and waveform protein, which leads to disruption of cell–cell junctions and triggers the EMT process, stimulating tumor cell metastasis [95].