Whereas the focus here is on neuronal proliferation and survival, it is important to note that ribosome biosynthesis is also critical for the formation and maintenance of dendritic growth, which has a high requirement for protein synthesis, and reductions in ribosomal proteins—including RPS6, RPS14, and RPL4, which are also reduced in our PAE model—lead to smaller dendritic trees and reduced neuronal connectivity [58], deficits also observed in preclinical models of PAE [59,60]. The gene discussed is RPS6; the disease is pulmonary artery enlargement.