In a double knock-in mouse model of AD, featuring mutations in both APP and presenilin-1, an age-related reduction in currents of AMPA receptors’ EPSPs in the presence of an NMDA receptor antagonist was observed, with further reductions in evoked EPSPs, spontaneous miniature EPSPs and evoked field EPSPs, recorded after Schaffer collaterals axon stimulation and AMPA receptor EPSPs recordings in CA1 cells [70]. Here, PSEN1 is linked to Alzheimer disease.