In contrast to SARS-CoV-2-induced transient upregulation of PLAT and THBD expression at 4 dpi (smFISH data), expression of anti-coagulant PLAT and THBD was suppressed in lung tissues at all tested time points post-infection, which, together with elevated TF, could be expected at the prothrombotic stage of infection. Here, THBD is linked to infection.