Thus, our objective in this study was to evaluate the RNA modulations of these key pathways in human macrophage in vitro models, PMA-differentiated THP-1 cells (THP-1/PMA), and primary monocyte-derived macrophages (MDMs) with induced constitutive expression of ACE2 enabling effective infection and restoring productive SARS-CoV-2 replication [18], and in a Golden Syrian hamster model, which recapitulates the pathophysiology of mild-to-moderate COVID-19 [47]. This evidence concerns the gene ACE2 and infection.