The prothrombotic shift in infected lungs was revealed by increased expression of the coagulation cascade mediators TF, PLAT, PAI-1, THBD, and vWF associated with endothelial dysfunction as shown through the upregulated expression of ESAM, CD106, CD201, VEGF-A, and VEGFR-2. This evidence concerns the gene SERPINE1 and endothelial dysfunction.