Apart from targeting Th2 immune response, which involves IgE, IL-4, IL-5, IL-13, IL-31, IL-18, IL-37, Janus kinase (JAK), OX 40, and IL-4R (a common receptor chain between IL-13 and IL-4), there are other potential targets, including mediators associated with conditions like psoriasis, such as IL-17, IL-36, or IL-22, which are being explored in clinical studies [63,64]. This evidence concerns the gene IL4 and psoriasis.