Furthermore, ascorbic acid was also able to improve depressive-like behaviors, hyperglycemia, and hypoinsulinemia, while also increasing the levels of monoamines, decreasing oxidative stress, and reducing the levels of TNF-α and IL-6 in the prefrontal cortex of a rat model of type 2 diabetes and comorbid depression [314]. This evidence concerns the gene IL6 and major depressive disorder.