Another study showed that an SFN-enriched diet inhibited the diabetes-induced rise in histone deacetylase 2 (HDAC2) activity which correlated with histone acetylation and the transcriptional activation of the bone morphogenetic protein (BMP)-7 promoter (related to TGF-β/Smad signaling) [164]. Here, HDAC2 is linked to diabetes mellitus.