Miyagaki and colleagues have evaluated the cytokine profiling of Th17 and Th22 response in the microenvironment of cutaneous T-cell lymphomas and found an upregulation of IL-22 and downregulation of IL-17A, which could explain the migration of dermal Langerhans cells and the low number of neutrophils, respectively [12]. The gene discussed is IL22; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.