The Akt phosphorylation of protein kinase C α (PKCα) regulates the actin cytoskeleton and various cellular functions; this pathway is crucial for the maintenance of normal and cancer cells through its involvement in multiple physiological functions, including cell cycle progression, transcription, translation, cellular differentiation, metabolism, motility, and apoptosis [12,31,34,45]. The gene discussed is AKT1; the disease is cancer.