In contrast to healthy volunteers, TIM3 expression percentages and MFI on CD8+ T cells proved significantly greater in RA patients (12.9 (20.255), (N = 48) vs. 7.5 (8.8), (N = 27), p = 0.0012; MFI: 457 (123.8), (N = 48) vs. 395 (106), (N = 27), p = 0.0001). This evidence concerns the gene HAVCR2 and rheumatoid arthritis.