CD127 expression percentages and MFI was significantly reduced on CD8+ T cells of RA patients compared to healthy volunteers (21.2 (22.63), (N = 48) vs. 40.2 (36.2), (N = 27), p = 0.0012; MFI: 352 (92), (N = 33) vs. 402 (102), (N = 25), p = 0.0003). This evidence concerns the gene CD8A and rheumatoid arthritis.