In a murine model, TIGIT engagement had been proven to ameliorate autoimmunity, and pathway modification is used to generate durable tolerance for the treatment of autoimmune conditions [15]. Interleukin-7 receptor-α (CD127) and common-γ chain receptor-formed heterodimer complex-driven IL-7 signaling is vital for naive T cell survival, additionally to the growth and survival of memory T cells, and exerts an impact on immune-mediated autoimmune diseases such as RA [16]. Here, TIGIT is linked to rheumatoid arthritis.