Serum from CS patients and elderly were analyzed using multi-analyte ELISArray (Qiagen kits), which assays 12 pro and anti-inflammatory cytokines in the same time (IL-1a, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17a, IL-13 and GM-CSF. Here, IL1B is linked to Cowden syndrome 1.