The percentage of CD4+ LT cells was significantly decreased in CS patients (24.43 ± 17.4) compared to both healthy young (18–29 years; 50.43 ± 9.16; p = 0.03), (30–45 years; 49.17 ± 6.251; p = 0.0207) and elderly groups (46–65 years; 48.38 ± 14.6; p = 0.01) (Figure 3a). The gene discussed is CD4; the disease is Cowden syndrome 1.