Hutchinson–Gilford Progeria syndrome (HGPS), which is characterized mostly by its accelerated normal human aging conditions [87,88], is caused by de novo mutations in the LMNA gene that activate an alternative pre-mRNA splice site leading to the expression of progerin—a lamin A mutant lacking 50 amino acids in its globular tail domain. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.