AKT1 and breast cancer: The therapeutic implication of TM in breast cancer: With several preclinical studies, TM could be a potential drug for treating BC with metastasis, as preclinical studies showed that TM blocks BC growth and metastasis through the regulation of the Akt/NF-kB-signaling pathway [43] and enhances trastuzumab antitumor activity on BC [44], suggesting a promising approach of combination therapy of TM and trastuzumab to improve trastuzumab’s clinical efficiency [44].