SIRT1 and osteoarthritis: Research has also underscored quercetin’s capacity to mitigate mitochondrial dysfunction and promote biogenesis in osteoarthritis-afflicted rats by increasing the expression levels of SIRT1, PGC-1α, NRF1, NFR2, TFAM, and phospho-AMPKα, suggesting its action through the AMPK/SIRT1 pathway [262,263].