In murine DSS-induced colitis, inosine attenuates the hallmarks of colitis and colonic levels of malondialdehyde (MDA), myeloperoxidase activity (MPO), major intrinsic proteins (MIP)-1α and -2 and proinflammatory cytokines IL-1, IL-6, IL-12 and TNF-α [128]. This evidence concerns the gene PROS1 and colitis.