HSPA1A and malignant colon neoplasm: Indeed, an antisense knockdown of HSPA1A/Hsp72 in human colon cancer-derived Caco-2 epithelial cells affected neither the transepithelial electrical resistance (TEER) nor the mannitol flux, which is indicative of an unaltered paracellular permeability for ions and small uncharged molecules, respectively [44,45].