AKT1 and central nervous system cancer: Importantly, it has been shown that [18], Notch1 signaling activity was elevated in GBM tissues, and downregulation of the Notch1 pathway by shRNA and MK0752 significantly inhibited the PI3K/AKT/mTOR signaling pathway and weakened the self-renewal, invasion, and tumor growth ability of glioma initiating cells.