CSF1R and central nervous system cancer: In fact, using an orthotopic, immunocompetent GBM mouse model, Almahariq et al. (2021) [11] showed that inhibition of CSF-1R with BLZ-945 enhanced the efficacy of RT in the glioma treatment and resulted in significantly improved mouse survival compared to RT alone or CSF-1R inhibition alone in murine gliomas.