Inhibition of CSF-1R can downregulate the three pathways (Figure 3b, Figure 5b, Figure 7b and Figure 9b), which will reduce the number of macrophages polarized to the pro-tumor M2 phenotype as observed in Akkari et al. (2020), and thus improve the survival of glioma mice [10]. This evidence concerns the gene CSF1R and glioma.